that ache you get in your head/body/mind/soul when classes are getting you down and you don't really feel smart or sexy. It can result in a loss of motor skills, excessive sleeping, not eating, and binge drinking. It is inadvisable to attempt to go on a date, sit in class for a long period of time, talk to someone you want to impress, or stray to far from a coffee pot when you are experiencing these symptoms. Apart from coffee the cures include a satisfying sexual experience, loud riotous music, or an injection of adrenaline. The latter is not recommended.
Friend: Hey are you high you look totally out of it?
You: Nah man, i had four classes today i got a major college-ache.