Top Definition
A disease you get from getting lucky.
Sypmtoms include but are not limited to; Inflated ego, sense of self importance, abandoning friends or changing their ways.
"So what exactly is wrong with John? He's changed since he got with Emma."
"Dunno, got serendiphilis, I guess."
โดย Honeymaid 07 สิงหาคม 2008

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